SELECTED PUBLICATIONS

 

 

Cellular shape reinforces niche to stem cell signaling in the small intestine
Pentinmikko N, Lozano R, Scharaw S, Andersson S, Englund JI, Castillo-Azofeifa D, Gallagher A, Broberg M, Song KY, Sola Carvajal A, Speidel AT, Sundstrom M, Allbritton N, Stevens MM, Klein OD, Teixeira A, Katajisto P.
Sci Adv. 2022 Oct 14;8(41):eabm1847. doi: 10.1126/sciadv.abm1847.

 

Retrograde movements determine effective stem cell numbers in the intestine

Azkanaz M, Corominas-Murtra B, Ellenbroek SIJ, Bruens L, Webb AT, Laskaris D, Oost KC, Lafirenze SJA, Annusver K, Messal HA, Iqbal S, Flanagan DJ, Huels DJ, Rojas-Rodríguez F, Vizoso M, Kasper M, Sansom OJ, Snippert HJ, Liberali P, Simons BD, Katajisto P, Hannezo E, van Rheenen J.

Nature. 2022 Jul;607(7919):548-554. doi: 10.1038/s41586-022-04962-0.

 

“Tonga”: A Novel Toolbox for Straightforward Bioimage Analysis

Ritchie A, Laitinen S, Katajisto P, Englund JI

Front. Comput. Sci. 2022 Mar 31, doi:10.3389/fcomp.2022.777458


 

Metabolic determination of cell fate through selective inheritance of mitochondria

Döhla J, Kuuluvainen E, Gebert N, Amaral A, Englund JI,
Gopalakrishnan S, Konovalova S, Nieminen AI, Salminen ES,
Torregrosa Muñumer R
, Ahlqvist K, Yang Y, Bui H, Otonkoski T, Käkelä R,
Hietakangas V, Tyynismaa H, Ori A, Katajisto P.

Nat Cell Biol. 2022 Feb;24(2):148-154. doi: 10.1038/s41556-021-00837-0.

 

Laminin alpha 5 regulates mammary gland remodeling through luminal cell differentiation

and Wnt4-mediated epithelial crosstalk

Englund JI, Ritchie A, Blaas L, Cojoc H, Pentinmikko N, Döhla J, Iqbal S, Patarroyo M, Katajisto P.
Development. 2021 Jun 15;148(12):dev199281. doi: 10.1242/dev.199281.


 

NOTUM from Apc-mutant cells biases clonal competition to initiate cancer

Flanagan DJ, Pentinmikko N, Luopajärvi K, Willis NJ, Gilroy K, Raven AP, Mcgarry L, Englund JI, Webb AT, Scharaw S, Nasreddin N, Hodder MC, Ridgway RA, Minnee E, Sphyris N, Gilchrist E, Najumudeen AK, Romagnolo B, Perret C, Williams AC, Clevers H, Nummela P, Lähde M, Alitalo K, Hietakangas V, Hedley A, Clark W, Nixon C, Kirschner K, Jones EY, Ristimäki A, Leedham SJ, Fish PV, Vincent JP, Katajisto P, Sansom OJ.

Nature. 2021 Jun;594(7863):430-435. doi: 10.1038/s41586-021-03525-z.

Notum produced by Paneth cells attenuates regeneration of aged intestinal epithelium

Pentinmikko N, Iqbal S, Mana M, Andersson S, Cognetta AB 3rd, Suciu RM, Roper J, Luopajärvi K,  Markelin E, Gopalakrishnan S, Smolander OP, Naranjo S, Saarinen T, Juuti A, Pietiläinen K, Auvinen P, Ristimäki A, Gupta N, Tammela T, Jacks T, Sabatini DM, Cravatt BF, Yilmaz ÖH, Katajisto P.

Nature. 2019 Jul;571(7765):398-402. doi: 10.1038/s41586-019-1383-0.

A Wnt-producing niche drives proliferative potential and progression in lung adenocarcinoma

Tammela T, Sanchez-Rivera FJ, Cetinbas NM, Wu K, Joshi NS, Helenius K, Park Y, Azimi R, Kerper NR, Wesselhoeft RA, Gu X, Schmidt L, Cornwall-Brady M, Yilmaz ÖH, Xue W, Katajisto P, Bhutkar A, Jacks T.

Nature. 2017 May 18;545(7654):355-359. doi: 10.1038/nature22334.

Asymmetric apportioning of aged mitochondria between daughter cells is required for stemness
Katajisto P, Döhla J, Chaffer CL, Pentinmikko N, Marjanovic N, Iqbal S, Zoncu R, Chen W, Weinberg RA, Sabatini DM.
Science. 2015 Apr 17;348(6232):340-3. doi: 10.1126/science.1260384.

mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake
Yilmaz ÖH, Katajisto P, Lamming DW, Gültekin Y, Bauer-Rowe KE, Sengupta S, Birsoy K, Dursun A, Yilmaz VO, Selig M, Nielsen GP, Mino-Kenudson M, Zukerberg LR, Bhan AK, Deshpande V, Sabatini DM.
Nature. 2012 Jun 28;486(7404):490-5. doi: 10.1038/nature11163.